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What is Cryopreservation? Dr. Hrishikesh Pai

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If you are a person who wants to have children but wants to prioritize your education or career first, then cryopreservation is one of the best methods to ensure that you can get pregnant later in life. 

In this article, Dr. Hrishikesh Pai, one of the best IVF doctor in Nagpur will discuss the different  types and methods and some of the advantages of cryopreservation.

Read on to know more about the article,

What is cryopreservation?

Cryo – preservation is the process where cells, tissues, organelles, extracellular matrix, and organs are preserved by cooling to low temperatures.

For cryopreservation to be used with optimal success it is essential that the entire protocol of freezing, storage, and thawing procedures is carried out in the precisely required and prescribed manner.

 The team concerned with freezing must, therefore, be appropriately equipped, experienced and informed to be able to preserve the maximum viability in the frozen samples. The team responsible for the recovery of this viability, by thawing, need not be specialized in the earlier stages of cryopreservation but must be appropriately skilled and knowledgeable

Two methods of cryopreservation 

The two methods of cryopreservation are:

  1. Slow freezing:

Slow freezing is a technique where the cells are cooled very slowly at around -196 C over the course of several hours. This temperature allows for the frozen eggs to be safely preserved- this temperature allows all the biological functions to stop inside the cell. This process is also called a controlled rate or slow programmable freezing.

Dr. Hrishikesh Pai, from IVF Bloom clinic, which is one among the top ten IVF hospitals in India, says that slow freezing was popular back in the mid-90s, but as of now vitrification is used as the process preserves the cells without any damage

We’ll be seeing about vitrification below,

  1. Vitrification

Vitrification is the opposite of slow freezing. Vitrification is a flash freezing method in which the cells are cooled quickly in a couple of minutes. 

According to studies, vitrification is a more successful method of preserving the cells than slow freezing, as in the slow freezing method, it is likely that ice crystals will form inside the cells. Ice crystals cause damage to the cell structures, and this will make the cell unfunctional after the thawing process. 

Vitrification uses higher concentrations of cryoprotectants (chemical compounds that prevent cells or tissues from damage due to freezing) to freeze the cells faster. This will prevent the cells from being damaged.

Types of freezable tissues

The different types of freezable tissues include;

  1. Egg(oocyte) freezing:

Human oocyte cryopreservation is a procedure to preserve a woman’s eggs. This technique has enabled women to postpone pregnancy to a later date – whether for medical or social reasons. 

Procedure for egg freezing

  • Ovarian stimulation: your doctor will give you drugs/medications that will trigger the ovaries to produce more eggs than usual. The medicines are given two weeks before retrieving the eggs.
  • Egg retrieval: The doctor will give you mild sedation and insert a transvaginal ultrasound into the vagina to locate the follicles. The doctor will place a needle to retrieve the eggs from the follicles. The doctor will extract up to 10-15 egg follicles. 
  • Egg freezing: The retrieved eggs are frozen to a sub-zero temperature to store for future use.
  1. Sperm freezing:

The procedure for sperm freezing is :

  • Your sperm will be collected at the lab.
  • The lab doctor will examine the quality and quantity of the sperm. 
  • The doctor will transfer only the high-quality sperm for the cryopreservation process, where your sperm will be stored for future use.
  1. Embryo cryopreservation:

High-quality embryos are frozen at sub-zero temperatures from fertilization to the blastocyst stage.

Procedure for embryo freezing

  • Your doctor will give you medications to stimulate the production of eggs. This will be done 2-3 weeks before removing the eggs.
  • Your doctor will retrieve the eggs from your follicle and incubate the removed eggs with sperms to fertilize them.
  • The fertilized eggs are cryopreserved after three to five days of fertilization.

Advantages of cryopreservation

Dr. Hrishikesh Pai, one of the best IVF doctors in Mohali, says that cryopreservation can benefit a lot of couples.

  • Delay pregnancy: The majority of women who choose to freeze their eggs prefer to put off having children until their 30s or early 40s. After 30, women’s eggs start to deteriorate in quality and quantity, making it harder to become pregnant and maintain a healthy pregnancy. Women who desire to postpone motherhood for personal reasons should save higher-quality eggs in their 20s.
  • Preimplantation Genetic Testing: Women worried about passing certain genetic disorders onto their children can have embryos undergo genetic testing before they are frozen. Embryos that do not have genetic disorders can then be screened out and used for uterine implantation purposes.
  • Beneficial for Women undergoing cancer treatment: Cancer therapies will negatively impact male and female fertility. Radiation and anti-cancer medications target egg and sperm cells’ DNA, which significantly lowers their viability. Cryopreservation gives women who wish to get pregnant but find out they need extensive cancer therapy the option of freezing eggs that can be used after they finish cancer treatments.
  • Unused frozen embryos for multiple pregnancies: Any extra embryos can be transplanted to boost the likelihood of conception if one frozen embryo transfer doesn’t result in a pregnancy. Dr. Hrishikesh Pai, one of the best IVF doctor in Mohali says only cryopreservation offers the benefit of having numerous frozen embryos ready for usage over an extended period of time. 
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4 Services CPAs Offer To Streamline Payroll Compliance

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Payroll rules change fast. Penalties hit hard. You need to get paychecks out on time and correct every single cycle. A trusted CPA cuts through that pressure. A skilled firm checks your payroll steps, watches for risk, and keeps your records clean for any review. With the right support, you spend less time worrying about tax notices and more time leading your team. This blog explains the 4 services CPAs offer to streamline payroll compliance so you can stop guessing and start following clear steps. You will see how a CPA reviews worker status, tracks tax deadlines, sets up strong controls, and prepares for audits. For businesses that want local insight, CPA Denver can also guide you through state and city rules that often cause confusion. By the end, you will know which services you need now and how to ask for them.

1. Worker classification and pay setup

Payroll starts with one basic question. Who counts as an employee and who does not. If you get that wrong, every check after that is exposed. A CPA reviews how each person works and how you control the work. Then the CPA compares that picture with federal and state rules.

The CPA helps you:

  • Sort workers into employee or contractor status
  • Set pay types such as hourly, salary, and piece rate
  • Apply overtime rules for non-exempt workers
  • Set up sick leave and family leave pay where laws require it

The IRS explains common worker status tests on its independent contractor page. A CPA takes that guidance and translates it into simple steps for your payroll system. This help protects you from back pay, extra tax, and interest.

2. Tax withholding, deposits, and filings

Next, a CPA focuses on payroll tax. Every paycheck triggers rules from the IRS and your state. Late or wrong payments cause sharp penalties. A CPA builds a clear schedule so you know what to send and when.

The CPA can:

  • Set up correct federal income tax withholding using Form W-4
  • Apply Social Security and Medicare limits
  • Handle state and local income tax where it applies
  • Plan deposit dates for payroll taxes
  • Prepare or review Forms 941, 940, W-2, and W-3

The IRS gives filing rules and dates in Publication 15. A CPA uses those rules to build a calendar for your business. You get a clear notice of each upcoming deposit and return. That structure cuts late fees and keeps your cash flow steady.

3. Payroll controls and recordkeeping

Strong records protect you when questions come up. They also help you spot mistakes before they spread. A CPA reviews how you track time, approve pay, and store documents. Then the CPA suggests controls that fit your size and tools.

Common controls include:

  • Separate people who input time from people who approve it
  • Review payroll reports before each pay run
  • Reconcile payroll totals to your bank and general ledger
  • Store pay records and tax forms for the required years

The U.S. Department of Labor explains basic record rules for wages and hours on its compliance pages. A CPA uses that base and adds state rules, which can be stricter. You end up with a simple checklist that your staff can follow every pay period.

4. Audit support and notice response

Even careful employers sometimes get a letter. It might come from the IRS, a state tax office, or a labor agency. The tone can feel harsh. A CPA gives calm support when that happens.

The CPA can:

  • Read each notice and explain what it really asks for
  • Check your payroll data against the issue raised
  • Prepare clear responses and supporting records
  • Talk with the agency on your behalf if you authorize it

With a CPA in your corner, you avoid rushed answers. You present clean records and simple explanations. That reduces extra questions and helps close the review faster.

How CPAs support payroll compliance: quick comparison

Service Main goal Key risks reduced Typical outcomes

 

Worker classification and pay setup Match worker status and pay rules to law Back wages, reclassification, extra tax Correct pay types and clean worker files
Tax withholding, deposits, and filings Send the right tax amount at the right time Late payment penalties and interest On time deposits and accurate returns
Payroll controls and recordkeeping Keep payroll data accurate and secure Fraud, missing records, repeat errors Strong checks and ready support documents
Audit support and notice response Handle questions from agencies with care Unpaid balances, extended exams Faster resolution and lower stress

How to choose the right CPA support

You do not need every service at once. Your needs change as your payroll grows. A short talk with a CPA helps you pick the right mix.

Consider three steps:

  • First, list your current payroll tasks and who handles them
  • Next, note any recent notices, late fees, or staff complaints
  • Then, ask a CPA to review one full pay cycle from time entry to tax deposit

That single review often uncovers the most painful weak spots. From there, you can add support for just those gaps. Over time, you build a payroll system that runs with fewer surprises and fewer long nights.

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Digital heart: how technology has rewritten the rules of love

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Imagine: at the turn of the century, talking about meeting someone online sounded almost like an awkward confession that required justification. Today, millions of people open dating apps as naturally as they check their email or browse the news. We live in an era where finding a significant other has become as digital a process as ordering a taxi or buying tickets. And it’s not just convenience — it’s a revolution in how we understand relationships, intimacy, and the very nature of human connections.

When the whole world is at your fingertips

The digitization of personal life did not begin yesterday, but the last decade has seen explosive growth. Smartphones have become pocket matchmakers, and algorithms have taken on the role previously played by mutual friends or chance encounters. The statistics are impressive: according to research, about 40% of couples in developed countries now meet online. That’s more than through friends, colleagues, or in bars.

Why did this happen? There are many reasons, and they are not only related to technological progress. Modern people live at a frantic pace: work, study, projects, hobbies. There is a catastrophic lack of time for spontaneous encounters. In addition, social circles often become closed — we see the same people day after day, and it becomes increasingly difficult to go beyond our familiar environment.

Digital platforms solve these problems elegantly. They open up access to thousands of potential partners, allow you to find out basic information about a person in advance, and weed out obviously unsuitable candidates. Geography is no longer an obstacle — you can communicate with someone from another city or even another country. And for shy people, the screen becomes a kind of shield, behind which it is easier to express yourself and start a conversation without fear of instant rejection.

Interestingly, online dating has democratized the romantic market. Previously, the chances of meeting someone depended on appearance, social circle, and social status. Now, a profile in an app gives you the opportunity to talk about yourself, show your interests, demonstrate your sense of humor or depth of thought. This does not negate the importance of first impressions, but it gives more chances to those who might go unnoticed in real life.

From text to video: the evolution of online communication

The first generation of dating sites was quite primitive — static profiles, correspondence, photo exchange. It worked, but it created a problem: there was often a gap between the virtual image and the real person. People could correspond for months, idealizing each other, only to discover upon meeting that the other person did not live up to their expectations.

Video chats changed the situation dramatically. They became a bridge between the digital and physical worlds, allowing people to see their conversation partner as they really are, hear their voice, and pick up on intonations and facial expressions. Platforms such as Thunder Omegle or CooMeet.chat offer a format of live communication that is as close as possible to a real date, while retaining the advantages of the online environment — safety, the comfort of home, and the ability to interrupt the conversation without awkwardness.

The video format solves several important tasks at once:

  • It confirms the person’s authenticity and that they match their profile photos.
  • It allows you to assess non-verbal cues and emotional compatibility.
  • It saves time on preliminary acquaintance before a face-to-face meeting.
  • It reduces the risks associated with deception and fraud.
  • It develops spontaneous communication skills in real time.

Psychologists note that video communication activates the same areas of the brain as a face-to-face meeting. We read micro-expressions on the face, react to the tone of voice, and feel the energy of the other person. This makes the acquaintance more comprehensive and helps to quickly understand whether there is real chemistry between people or whether it is just a successful correspondence.

The light and shadow of digital romance

It would be naive to think that the technologization of relationships is only beneficial. Like any powerful phenomenon, it has a downside. One of the main problems is the effect of endless choice. When you have hundreds and thousands of profiles in front of you, you get the illusion that your ideal partner is somewhere nearby, you just need to keep looking. People become more picky, less tolerant of flaws, and more quickly disappointed.

The swipe culture has turned dating into a kind of shopping. People are judged in a matter of seconds based on a couple of photos and a short description. This is superficial and often unfair — a bad selfie can hide an amazing personality, and a perfectly edited profile can hide emptiness. The speed and ease with which one can reject or be rejected creates a kind of emotional burnout.

Another pitfall is the gap between online image and reality. In the digital environment, it is easy to present oneself in the best light: choose the most flattering photos, think up witty responses, and hide uncomfortable aspects of one’s personality.

Some people become so immersed in creating the perfect virtual “me” that they lose touch with their own authenticity. And when it comes to meeting in real life, the masks come off, and it can be painful for both parties.

Research also shows that excessive use of dating apps can affect self-esteem. Constantly comparing yourself to others, depending on likes and matches, and fearing rejection all create psychological stress. Young people are especially vulnerable, as digital validation becomes a key indicator of their self-worth.

What awaits us tomorrow

Technology is not standing still, and the future of online dating promises to be even more exciting. Artificial intelligence has already learned to analyze people’s compatibility not only based on profile data, but also on behavior patterns, communication style, and even voice tone. Virtual reality is preparing to offer full-fledged dates in digital space, where you can walk through virtual parks or sit in a simulated café while being on opposite sides of the world.

But no matter how far progress goes, it is important to remember the main thing: technology is a tool, not a substitute for real human feelings. Algorithms can bring people together, but only people themselves are capable of creating true intimacy. No app can replace the ability to listen and hear, accept your partner’s flaws, and work on your relationship during difficult times.

The digital revolution has given us incredible opportunities to find our soul mate. It has broken down old barriers and limitations, giving millions of people who would otherwise never have met a chance to connect. But success depends on how wisely we use these tools. The main thing is not to get lost in endless swiping, not to forget that behind every profile is a real person with their own hopes and fears. And that true love requires not only a successful matching algorithm, but also a willingness to open your heart.

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5 Common Myths About Veterinary Visits Debunked

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Many people avoid veterinary visits because of fear, cost, or past frustration. As a result, pets miss early signs of pain and disease. You may worry your pet will be stressed, that vaccines are unsafe, or that indoor pets never need checkups. These beliefs feel true when life is busy and money is tight. Yet they quietly put your pet at risk. This blog cuts through five common myths about vet visits and shows what actually protects your pet. It draws on what teams at an animal hospital in Guelph see every day. You will see how regular exams catch problems early, how modern clinics reduce stress, and how honest talks about cost give you real control. By the end, you can walk into your next appointment with clear expectations and less fear. Your pet depends on your choices.

Myth 1: “My pet looks healthy, so we can skip checkups.”

Pets hide pain. That is how many animals survive in the wild. By the time you see clear signs, the disease is often advanced.

During a routine exam, the vet checks:

  • Heart and lungs
  • Teeth and gums
  • Eyes, ears, and skin
  • Joints and weight

Each check looks simple. Together, they can uncover heart disease, kidney problems, arthritis, and early cancer. The Centers for Disease Control and Prevention explains that healthy pets also protect human health. Regular care lowers the risk of germs that pass between pets and people.

Here is how “my pet looks fine” can differ from what the vet finds.

What you see at home Possible hidden problem What the vet may detect early

 

Normal eating with slight weight loss Thyroid or kidney disease Abnormal bloodwork and heart changes
“Dog breath” that seems usual Dental infection Loose teeth and gum disease
Slowing down with age Arthritis or heart disease Pain on joint movement or heart murmur
Staying quiet in one room Chronic pain or low mood Tense muscles and high pulse

Early treatment costs less. It also spares your pet long suffering.

Myth 2: “Vaccines are unsafe and do more harm than good.”

Fear of vaccines is strong. Yet the evidence is clear. Vaccines prevent deadly diseases in pets and protect people.

The American Veterinary Medical Association explains that vaccine reactions are uncommon. When they occur, they are usually mild and short. Common signs include:

  • Tiredness for one day
  • Slight swelling at the shot site
  • Low appetite for one meal

Severe reactions are rare. Vets track them and adjust vaccine plans when needed. You can ask about:

  • Core vaccines that protect from deadly disease
  • Noncore vaccines based on lifestyle and risk
  • Length of protection and booster timing

You protect your pet when you vaccinate. You also protect children, seniors, and people with weak immune systems who live with or visit your home.

Myth 3: “Indoor pets do not need regular vet visits.”

Indoor pets face fewer outside threats. They still face disease, injury, and age.

Cats and small dogs often hide sickness for months. They may use the litter box less, sleep more, or eat a bit less. These changes can be early signs of:

  • Diabetes
  • Kidney disease
  • Heart disease
  • Dental disease

Indoor pets also gain weight easily. Extra weight strains joints and the heart. A yearly exam lets your vet track weight, adjust food, and plan play that fits your pet.

Even indoor pets need protection from rabies and some parasites. Wildlife can enter yards and homes. Fleas and ticks can ride in on clothing. Simple tests and preventives limit this risk.

Myth 4: “Vet visits only matter during emergencies.”

Emergency visits are urgent, costly, and frightening. Preventive visits are calm, planned, and focused on your control.

During routine care, you and your vet can:

  • Review food, treats, and weight goals
  • Plan parasite prevention
  • Discuss behavior issues before they grow
  • Set up bloodwork for older pets

Here is a simple comparison.

Routine visit Emergency visit

 

Scheduled at a good time for you Unplanned and often at night
Lower and more predictable cost High cost with added tests
Pet often calm and stable Pet in pain or distress
Focus on prevention and planning Focus on crisis and fast choices

You lower the chance of a crisis when you keep up with routine visits. You also protect your budget and your peace of mind.

Myth 5: “My pet will be too stressed at the clinic.”

Fear is real for many pets. Clinics now use methods that reduce stress for both pets and families.

You can ask your vet team about:

  • Waiting in your car until a room is ready
  • Separate cat and dog spaces
  • Quiet exam rooms with soft surfaces
  • Slow handling with treats and praise

You can also help at home. You can:

  • Leave the carrier out all week with a soft blanket
  • Take short car rides that do not end at the clinic
  • Bring a favorite toy or towel that smells like home

Some pets need medicine before visits to ease fear. This is not a failure. It is kind care that allows safer exams and procedures.

Taking the next step

Myths grow in silence. Honest talks with your vet replace fear with clear choices. You protect your pet when you:

  • Schedule regular exams based on age and health
  • Keep vaccines and parasite prevention up to date
  • Call early when you notice even small changes

Your pet cannot speak. You speak through the choices you make. Regular veterinary care turns a quiet risk into clear action.

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